GLP-1and diabetes. Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino-acid-long peptide hormone deriving from tissue-specific posttranslational processing of the proglucagon peptide.
Mar 21, 2026 ·The incretin hormoneGLP-1is secreted by intestinal L-cells and plays a central role in metabolicregulation, most notably by augmenting glucose-stimulated insulinsecretionand promoting satiety [1, 2]. Beyond glycemia,GLP-1receptors are widely distributed across the pancreas, central nervous system, and cardiovascular tissues, where they mediate diverse physiological effects, including ...
Feb1, 2021 ·Pleiotropic signalling by G protein–coupled receptors is subject to spatiotemporalregulation, which allows precise control over a diverse range of cellular outputs. The glucagon-like peptide-1receptor (GLP-1R), a class B G protein–coupled receptor important in the control of blood glucose and energy homeostasis, is subject to redistribution within nanoregions of the plasma membrane and ...
Mar1, 1997 ·Thetemporalpattern ofGLP-1secretionwas analyzed by discrete deconvolution (DESADE) using a one-compartment model (28) with a plasma half-time ofGLP-1calculated from the original time series as previously described (25).
rhythmregulationon various metabolic processes, includingGLP-1secretion, which plays an essential role in the development of various metabolic diseases. Herein, we focused onGLP-1and its circadian rhythm to explore the factors.
RegulationofGLP-1secretionby ingested nutrients. After a meal, nutrients in the duodenum activate a proximal-distal neuroendocrine loop, which stimulatesGLP-1secretionfrom L-cells in the ileum and colon.
